Mr. Khai Sing, LAM B. Med. Sci, BM. BS, FRCS (Edin), FRCS (Orth)
Consultant Orthopaedic and Spine Surgeon

Guy`s and St Thomas` NHS Foundation Trust

Appointed January 2004

Apr 02 to Mar 03
Spine Fellowship
Messrs. B J Freeman, M P Grevitt, S H Mehdian, J K Webb
Centre for Spinal Studies and Surgery, University Hospital, Nottingham

May 7th to June 4th  European Spine Travelling Fellowship (2003)

Jun 03 to Dec 03  
Locum Consultant Spinal Surgeon (for Mr J W Webb)
Centre for Spinal Studies and Surgery, University Hospital, Nottingham

• Founding Member of IGASS (International Group for the Advancement of Spinal Science) – formerly GICD and European Spine Panel
• Member of the Expert Group AO Spine TK in Atraumatic or Minimal Access Surgery to the Spine
• Member of US and European Spinal Deformity Study Group (E-SDSG)
• AO Spine International Teaching Faculty
• AO Spine Europe Teaching Faculty
• AO Spine UK Teaching Faculty
• Advisory Editorial Board to European Spine Journal
• Spine Advisor to the Egyptian Ministry of Health
• Spine Advisor and Visiting Consultant Programme to U.A.E. Ministry of Health
• Spine Advisor and Visiting Consultant Programme to Kuwait Ministry of Health
• AO/Synthes Training Centre for Anterior Access Lumbar Spine Surgery

EDUCATION

• B. Med. Sci. Nottingham July 1988
• BM.BS  Nottingham   July  1990
• FRCS  Edinburgh    June 1994
• FRCS (Trauma and Orthopaedics)  Edinburgh  May  2001

• Managing Ionizing Radiation 1990, 1997
• ECFMG (Day 2) 1991
• Basic Course in Laparoscopic Surgery May 1996
• ATLS 1998    
• CCST  Mar 2003
• Lumbar disc replacement (Prodisc L) - Montpellier Oct 2003
• Vertebroplasty   - St George’s Hospital   8 May 2004                 
• Cervical disc replacement surgery (Prodisc C)  Jul 2004
• Kyphoplasty – Leiden (Kyphon)  6 Sept  2004

RESEARCH GRANTS

AWARDING ORGANISATION

 

• Nottingham Hospital Special Trustees: £3000 - Jan 95 to Jan 96
  Study: ‘Clinical efficacy of colchicine in the treatment of back pain and sciatica’
• Wishbone Trust: £25024 -Oct 96 to Oct 97
  Study: ‘Signal transduction in degenerative disc disease’
  Study into the molecular and cellular pathomechanisms in degenerative disc disease
  Work submitted towards MD Thesis (1 Sept 2003)
  Use of funds:
  a. Laboratory equipment and materials
  b. PhD laboratory assistant (full-time) under my supervision
• Smith and Nephew Foundation: £25,000 -Aug 99 - Aug 2000
  Study:  ‘Bio-molecular mechanisms in degenerative disc disease’
  Use of funds:
  MD Thesis project funding for Research Fellow (submitted and awarded)
• Spinal Osteoporosis Research Nurse: £35,000 -12 mths
  From Kyphon
• Spinal Research Fellow: £30,000 - 36 mths

• Twin studies: collaboration with Twin Study group at St Thomas’ Hospitals. Clinical and radiological review (MRI and X-rays) of 300 twins
• Lumbar Disc Arthroplasty: Prospective 2 year review of 150 lumbar disc replacements (Prodisc-L)
• Reference Centre for motion preservation surgery: Current discussions to turn Guy’s and St Thomas’ into a reference centre for 1) lumbar disc replacement, 2) cervical disc replacement, 3) nucleus replacement or any other new development relating to motion preservation of the spine

• Smith and Nephew Travel Fellowship Award (Runner up): 27th BOA Instructional Course, 9-11 Jan 1998, York, UK
  Paper: ‘Lumbar disc High-Intensity zones: The value and significance of provocative discography in the determination of the discogenic pain source’
• New Investigator Research Award: 3rd World Combined Orthopaedic Research Societies of USA, Japan, Canada and Europe, 28-30 Sept 1998, Hamamatsu, Japan
  Paper: ‘Abnormal signal transduction in degenerative disc disease: The role of tyrosine phosphorylated Annexin I & II proteins’
• Spine Society of Europe: (Runner up 1998)
  Paper: ‘Abnormal signal transduction in degenerative disc disease: The role of tyrosine phosphorylated Annexin I & II proteins’
• Mansfield Medical Society ''Doctor of the Year Award'' (Runner up): - 12 Jan 2000
  Paper: ‘Abnormal signal transduction in degenerative disc disease: The role of tyrosine phosphorylated Annexin I & II proteins’
• East Midlands Research Prize: East Midlands Research Society, 17 Nov 2000, Leicester     
  Paper: Proteome alterations in degenerative disc disease: the significance of reduced lysozyme-C-like levels
• 2001 Jackson and Waugh Research Prize (Nottingham): 22 Jun 2001
  Best published paper: ‘Lumbar disc High-Intensity zones: The value and significance of provocative discography in the determination of the discogenic pain source.’ Eur Spine J, 2000;9(1):36-41
• Malkin Memorial Prize (Nottingham): 27 Jun 2003
  Paper: ‘Do vertebral end plate changes correlate with discogenic low back pain? – A single blinded prospective study’ (Y L Leung, K S Lam, J K Webb)
• Best poster finalist, 5th Eurospine, Prague, Czech Republic: 1-4 Oct 2003
  Paper: C7 pedicle subtraction osteotomy and decancellisation followed by cevico-thoracic segmental fixation in ankylosing spondylitis (DP Tokala, KS Lam, BJ Freeman, JK Webb)
• Best paper Britspine 2006, Cardiff, UK: Oct 26-28th 2006
  Paper: The effect of spinal surgery on function in children with neuromotor disorders and scoliosis: Prospective study using standardised measures. (NJ Courtier, JK O’Dowd, EA Will, JD Lucas, K Lam, E Wraige)

• The effects of simple trauma to patients with cervical spine neurofibromatosis
  KS Lam, SH Mehdian, B White. Eur Spine J 1997;6:77-80
• Medical decompression of spinal hydatidosis
  KS Lam, A Faraj, RC Mulholland. Spine 1997;22(17):2050-2055
• Fatal venous air embolism in spinal surgery: A serious cause for consideration
  KS Lam, SH Mehdian
  JBJS(B) 1996;78-B(Supp II and III):163
  JBJS(B) 1997;79-B(Supp I):111
• Laparoscopic assisted anterior interbody fusion: A safe and justifiable method?
  KS Lam, T Freisem, JK O’Dowd, RC Mulholland, JK Webb
  JBJS(B) 1997;79-B(Supp I):99
• Surgical decompression: a life saving procedure for an extensive spinal epidural abscess
  KS Lam, K Pande, SH Mehdian
  Eur Spine J 1997;6:332-335
• Laparoscopic spinal fusion: First and second generation instrumentation           
  T Freisem, Y Leitner, R Gepstein, JK O’Dowd, KS Lam
  JBJS(B) 1997;79-B(Supp III):331
• The importance of the abdominal musculature mechanism in maintaining spinal sagittal balance: Case illustration in prune-belly syndrome
  KS Lam, SH Mehdian
  Spine 1999;24(7):719-722
• Apoptosis: The coming of age in disc research?
  KS Lam, TJ Baldwin, RC Mulholland
  JBJS(B) 1999;81-B(Supp III):271
• Abnormal signal transduction in degenerative disease disc disease: The role of tyrosine phosphorylated Annexin I & II proteins
  KS Lam, TJ Baldwin, RC Mulholland
  JBJS(B) 1999;81-B(Supp III):271
• Lumbar disc high-Intensity zones: The value and significance of provocative discography in the determination of the discogenic pain source
  KS Lam, D Carlin, RC Mulholland
  JBJS(B) i) 1998;80-B(Supp III) ii) 1999;81-B(Supp III):276
  Eur Spine J 2000;9(1):36-41
• The reliability of Adams' classification for discogram morphology
  ID Agorastides, KS Lam, BJ Freeman, RC Mulholland
  Eur Spine J 2000;9(4):309
• Sand pits and bucket handles: A case of bilateral traumatic bucket-handle tears of the medial menisci
  J Abbott, KS Lam, VM Srivastava, A Moulton
  Arthroscopy 2000;16(6):12
• Stress fracture of the sacrum: A rare cause of low back pain in a child
  KS Lam, A Moulton
  Ann Rheum Dis 2001;60:87-88
• The Adams classification for cadaveric discograms: inter- and intra-observer error in the clinical setting
  ID Agorastides, KS Lam, BJ Freeman, RC Mulholland
  Eur Spine J 2002;11(1):76-9
• The importance of early diagnosis in the management of proximal tibiofibular dislocation: a 9- and 5-year follow-up of a bilateral case
  A Aladin, KS Lam, EP Szypryt
  Knee 2002;9(3):233-6
• Wrist function after excision of the pisiform
  KS Lam, S Woodbridge, FD Burke
  J Hand Surg 2003 (Br & Eur);28B(1):69 – 72
• Malignant necrotising streptococcal myositis: a rare and fatal condition
  KN Subramanian, KS Lam
  JBJS (Br) 2003;85-B:277-8
• To fuse or not to fuse the lumbar disc high intensity zone? And the influence of discography
  KS Lam, ID Agorastides, JK Webb, RC Mulholland
  Eur Spine J 2002;11(S1)
• Radical changes in lysozyme distribution in degenerative disc tissue: Aetiology to disease?
  KS Lam, MS Sekowski, K Bishop, TJ Baldwin, RC Mulholland
  Eur Spine J 2002;11(S1)
• Do vertebral end-plate changes correlate with discogenic low back pain? A single blinded prospective study
  KS Lam, Y Leung, JK Webb
  Eur Spine J 2003;12(S1):S19
• C7 pedicle subtraction osteotomy and decancellisation followed by cervicothoracic segmental fixation in ankylosing spondylitis
  DP Tokala, KS Lam, BJ Freeman, JK Webb
  Eur Spine J. 2003;12(S1):S44
• The Modic classification: Inter- and Intraobserver error in clinical practise
  A Jones, A Clarke, BJ Freeman, KS Lam, MG Grevitt
  Spine 2005; Aug 15;30(16):1867-9
• Is there a role for selective anterior instrumentation in neuromuscular scoliosis?
  DP Tokala, KS Lam, BJ Freeman, JK Webb
  Eur Spine J; 2006 May 5; [Epub ahead of print]
• Ossification of the proximal thoracic ligamenta flava causing acute myelopathy in a Caucasian: case report and literature review
  Tokala DP, Lam KS, Prince HG
  Spinal Cord. 2007 Apr; 45(4):310-3 [Epub 2006 Jun 27]
• Pathological Hangman’s fracture after successful renal transplantation
  SS Al-Nammari, AA Khan, JD Lucas, KS Lam
  Acta Orthop Belg. 2006 Dec; 72(6):775-8
• C7 decancellisation closing wedge osteotomy for the correction of fixed cervico-thoracic kyphosis
  DP Tokala, KS Lam, BJ Freeman, JK Webb
  Eur Spine J. 2007 Sep; 16(9):1471-8. Epub 2007 Mar 3
• Haematogenous Methicillin Resistant Staphylococcus Aureus (MRSA) Spondylodiscitis
  SS Al-Nammari, JD Lucas, KS Lam,
  Spine 2007. Oct 15; 32(22): 2480-6
• Significant Correlation between cerebropsinal fluid nitric oxide concentrations and neurologic prognosis in incomplete cervical cord injury – Reviewer’s comment
  KS Lam
  Eur Spine J. 2008 Feb; 17(2):287-8. Epub 2007 Aug 22

INVITED PAPERS

1. Abnormal signal transduction in degenerative disease disc disease: The role of tyrosine phosphorylated Annexin I & II proteins
   KS Lam, TJ Baldwin, RC Mulholland
   Invited by Spine and Eur Spine J
2. Lumbar disc high-Intensity zone: The value and significance of provocative discography in the determination of the discogenic pain source
   KS Lam, D Carlin, RC Mulholland
   Invited by Spine and Eur Spine J
   Published - Eur Spine J 2000; 9:36-41

1. Discitis (Peer reviewed)
   KS Lam, JK Webb
   Hosp Med. May 2004; 65(5):280-6. (Review)
2. Lumbar Disc Arthroplasty: An update
   K S Lam
   Hospital Doctor. Nov 2005
3. An update on Lumbar Disc Arthroplasty
   KS Lam
   HCA Newsletter. Jan 2006
4. Lumbar stabilisation techniques (Peer reviewed)
   S Lau and KS Lam
   Current Orthopaedics. 2007, 21(1), 25-29

1. Minimal Access Spinal Surgery
   KS Lam
   a. Arab Health Magazine
   b. NHS Health Technology Magazine
   c. HCA Magazine
2. An update on Minimal Access Spinal Surgery
   KS Lam
   Capital Doctor